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Research Intelligence

ScienceView

Vol. 2026 · Daily Edition

Latest Findings from the Research Community

Summaries of recent studies and institutional announcements across health, artificial intelligence, physical sciences, environmental research, and social science.

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Top Science News

Daily refreshed highlights from the latest research intake

Health & Medicine

An Inhalable Hybrid Nitric Oxide Nanogenerator for Lung Adenocarcinoma Treatment via Bioorthogonal-Activated Gas-Immunotherapy.

Nitric oxide (NO) holds promise for circumventing resistance to platinum-based chemotherapy by reprogramming the tumor microenvironment (TME) in lung adenocarcinoma (LUAD). However, their further application is greatly hindered by uncontrolled release kinetics and off-target toxicity. Herein, an inhalable NO nanogenerator (10m@FOMs-Cu) that reprograms the TME via specific NO release is developed by encapsulating a biorthogonal-activated NO-cisplatin prodrug into TME-responsive hybrid micelles, a

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Environment

Ammonia Diverts Ozonolysis from C═C Scission to Nitrogen Incorporation via Competitive Adsorption and Nucleophilic Trapping.

The reaction of ozone with unsaturated organic compounds is a fundamental process in chemistry, central to both synthetic transformations and environmental molecular cycling. Here, we reveal a mechanistic branching in the Criegee ozonolysis of squalene, a model poly unsaturated triterpene, induced by gaseous ammonia, a ubiquitous nucleophile. Our experimental findings reveal that NH3 suppresses the ozone uptake by a factor of ∼3, an inhibition traced to competitive adsorption. DFT calcula

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Environment

Orientational Order of Linkers Controls ZIF-8 Crystallization.

Zeolitic imidazolate framework-8 (ZIF-8) crystallizes through an amorphous intermediate, but the molecular events that trigger nucleation within this disordered phase have remained elusive. Here we introduce a dynamic-binding, implicit-solvent force field for the ionic building units of ZIF-8 that enables unbiased microsecond-scale molecular dynamics of the full crystallization pathway─from solvated monomers to a 10 nm ZIF-8 nanocrystal. Our simulations reproduce the experimentally observ

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Physical/Tech

Thermochemical Polarization-Driven Heterolytic Hydrogenation in an Electrochemical Palladium-Membrane Reactor.

Heterolytic hydrogenation via hydride species transfer represents a fundamental transformation in industry for chemical synthesis, but H2 or organic hydride donors are often utilized as the hydrogen source. An electrochemical palladium (Pd) membrane reactor shows the ability to catalyze heterolytic reactions by using water as the hydrogen source, but quantitative descriptions of this reactivity remain absent, and the reaction often relies on external polarization of the chemical compartment. Her

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Health & Medicine

Why did some viruses evolve to be giants while others did not?

Viruses are ubiquitous mobile genetic elements that are obligate symbionts of cellular life forms and replicate exclusively within host cells. The current taxonomy of viruses includes 10 realms (the top rank taxon), 8 of which have small genomes in the range of one to about 60 kilobases and commensurately small virions. However, the two realms of viruses with double-stranded DNA genomes, Varidnaviria and Duplodnaviria , include several groups of viruses known as giant viruses, with genomes reach

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Health & Medicine

Mitochondrial ATP promotes T cell differentiation through chromatin accessibility.

Immune elimination of chronic infection or cancer requires cytotoxic CD8 + T cells that adopt and maintain an effector phenotype. Cytotoxic T cell function is a bioenergetically demanding process. Here, we report the ability of D-α-hydroxybutyrate (DAHB) to act as a signaling molecule that increases mitochondrial ATP production and drives the conversion of proliferating T cells into cytotoxic effector cells. DAHB signaling switches ATP production from glycolysis to oxidative phosphorylatio

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Health & Medicine

Metax enables accurate cross-domain taxonomic profiling of metagenomes.

Taxonomic profiling is fundamental to microbiome research, yet achieving high species-level accuracy remains challenging for complex communities that span bacteria, viruses, eukaryotes, and archaea, and these limitations are exacerbated in low-biomass, host-dominated samples. We introduce Metax, a cross-domain taxonomic profiler that integrates coverage-based probabilistic modeling with an expectation-maximization framework to distinguish true microbial signals from artifacts. Across >600 sam

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Health & Medicine

Glycocalyx-edited mesenchymal stem/stromal cell therapy in advanced osteoporosis.

Mesenchymal stem/stromal cells (MSCs) are osteoregenerative; however, their therapeutic efficacy for skeletal conditions is hampered by poor bone-homing ("osteotropism"). In preclinical models, this deficit is correctable by MSC glycocalyx editing to enforce sialylated Lewis X (sLeX) expression, thereby programming osteotropism. We conducted a first-in-human clinical trial (ClinicalTrials.gov: NCT02566655) involving a single intravenous infusion of glycocalyx-edited autologous bone marrow-derive

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Recommended Reading

Editor-recommended articles worth your attention

RecommendedArtificial Intelligence

Neural network-augmented Pfaffian wave-functions for scalable simulations of interacting fermions.

Developing accurate numerical methods for strongly interacting fermions is crucial for improving our understanding of various quantum many-body phenomena, especially unconventional superconductivity. Recently, neural quantum states have emerged as a promising approach for studying correlated fermions, highlighted by the hidden fermion and backflow methods, which use neural networks to model corrections to fermionic quasiparticle orbitals. In this work, we expand these ideas to the space of Pfaff

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RecommendedHealth & Medicine

PLASTID ENVELOPE ION CHANNELS (PEC1/2) link Ca 2+ and jasmonic acid signaling in plant cells.

Plants constantly encounter adverse environmental interactions. One organelle is particularly specialized in stress signaling and phytohormone synthesis: the plastid. Calcium (Ca 2+ ), a key second messenger, is known to intersect with cellular phytohormone signaling networks. While cytosolic Ca 2+ dynamics have been studied extensively, the physiological relevance of stromal Ca 2+ transients and the identity of channels mediating rapid Ca 2+ flux into plastids remain largely unexplored. In this

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RecommendedHealth & Medicine

Structural insights into fosfomycin efflux by a streptococcal ABC transporter.

Gram-positive bacteria encode a broad array of ABC transporters that mediate substrate translocation across the cell membrane, with some contributing to their survival under environmental stresses such as antimicrobial exposure. While several of these transporters have been shown to exhibit multidrug efflux activity, the functional roles of many others remain unknown. Here, using an efflux pump screen in the opportunistic human pathogen Streptococcus pneumoniae , we identified a previously uncha

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RecommendedPhysical/Tech

Multiband condensate of magnons in two dimensions.

Wavelike bosonic particles can accumulate in a single mode characterized by a particular wavelength, and such condensates are at the heart of phenomena such as superconductivity and superfluidity where usually a single complex number describes their state. If there are several flavors of excitations or particles, a vector containing several complex numbers can characterize multicomponent condensation, thus opening new possibilities for textures, dynamics, and devices. Thus far, multicomponent co

Continue reading
RecommendedSociety & Culture

Cerebellar microcircuits enable robust evidence-based decisions through cortico-cerebellar coupling.

The cerebellum is increasingly implicated in perceptual decision-making, yet it remains unclear how the cerebellar cortex can support sparse evidence accumulation over behavioral time scales without assuming cortical-style dense local excitatory recurrence. We present a biologically constrained modeling framework showing that cerebellar microcircuits can implement graded accumulation and competition in the absence of such recurrence. In our model, type-II Purkinje-neuron excitability generates f

Continue reading
RecommendedPhysical/Tech

Indirect reciprocity with dual private assessment.

People often cooperate out of concern for their reputation. The corresponding theory of indirect reciprocity predicts that such cooperation can only evolve if people's opinions of each other are sufficiently correlated. This correlation, however, can be difficult to achieve when individuals form their opinions independently from one another, as in private assessment models. In that case, errors can generate disagreements that propagate throughout a population. Here, we identify a simple mechanis

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Latest Headlines

Last updated Sep 14, 2026, 5:18 AM GMT+8

Artificial Intelligence

Neural network-augmented Pfaffian wave-functions for scalable simulations of interacting fermions.

Developing accurate numerical methods for strongly interacting fermions is crucial for improving our understanding of various quantum many-body phenomena, especially unconventional superconductivity. Recently, neural quantum states have emerged as a promising approach for studying correlated fermions, highlighted by the hidden fermion and backflow methods, which use neural networks to model corrections to fermionic quasiparticle orbitals. In this work, we expand these ideas to the space of Pfaff

Continue reading
Health & Medicine

PLASTID ENVELOPE ION CHANNELS (PEC1/2) link Ca 2+ and jasmonic acid signaling in plant cells.

Plants constantly encounter adverse environmental interactions. One organelle is particularly specialized in stress signaling and phytohormone synthesis: the plastid. Calcium (Ca 2+ ), a key second messenger, is known to intersect with cellular phytohormone signaling networks. While cytosolic Ca 2+ dynamics have been studied extensively, the physiological relevance of stromal Ca 2+ transients and the identity of channels mediating rapid Ca 2+ flux into plastids remain largely unexplored. In this

Continue reading
Health & Medicine

Structural insights into fosfomycin efflux by a streptococcal ABC transporter.

Gram-positive bacteria encode a broad array of ABC transporters that mediate substrate translocation across the cell membrane, with some contributing to their survival under environmental stresses such as antimicrobial exposure. While several of these transporters have been shown to exhibit multidrug efflux activity, the functional roles of many others remain unknown. Here, using an efflux pump screen in the opportunistic human pathogen Streptococcus pneumoniae , we identified a previously uncha

Continue reading
Physical/Tech

Multiband condensate of magnons in two dimensions.

Wavelike bosonic particles can accumulate in a single mode characterized by a particular wavelength, and such condensates are at the heart of phenomena such as superconductivity and superfluidity where usually a single complex number describes their state. If there are several flavors of excitations or particles, a vector containing several complex numbers can characterize multicomponent condensation, thus opening new possibilities for textures, dynamics, and devices. Thus far, multicomponent co

Continue reading
Society & Culture

Cerebellar microcircuits enable robust evidence-based decisions through cortico-cerebellar coupling.

The cerebellum is increasingly implicated in perceptual decision-making, yet it remains unclear how the cerebellar cortex can support sparse evidence accumulation over behavioral time scales without assuming cortical-style dense local excitatory recurrence. We present a biologically constrained modeling framework showing that cerebellar microcircuits can implement graded accumulation and competition in the absence of such recurrence. In our model, type-II Purkinje-neuron excitability generates f

Continue reading
Physical/Tech

Indirect reciprocity with dual private assessment.

People often cooperate out of concern for their reputation. The corresponding theory of indirect reciprocity predicts that such cooperation can only evolve if people's opinions of each other are sufficiently correlated. This correlation, however, can be difficult to achieve when individuals form their opinions independently from one another, as in private assessment models. In that case, errors can generate disagreements that propagate throughout a population. Here, we identify a simple mechanis

Continue reading
Health & Medicine

Detection of "hidden" mitotic crossovers by long-read DNA sequencing.

Mitotic crossovers in diploid organisms are usually detected by looking for loss of heterozygosity (LOH) for a marker. Assuming the crossover occurs between two duplicated chromatids, a single reciprocal crossover will result in two recombinant chromatids and two nonrecombinant chromatids. LOH will only be observed when a recombinant chromatid cosegregates with a nonrecombinant chromatid. Cells containing both recombinant chromosomes will not result in LOH. Below, we use long-range DNA sequencin

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Health & Medicine

Amino acid homeostasis by CORVET/HOPS: A metabolic and stress resilience checkpoint for T cells.

Amino acid sufficiency is critical for T cell metabolic reprogramming, yet how T cells maintain amino acid homeostasis remains poorly defined. Here, we identify the CORVET and HOPS (CORVET/HOPS) tethering complexes as essential upstream regulators. In activated T cells, they sustain intracellular amino acid levels by promoting macropinocytosis to acquire extracellular nutrients. This function enables dual signaling outcomes: suppression of the integrated stress response (ISR) and activation of m

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By Discipline

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Health & Medicine

PLASTID ENVELOPE ION CHANNELS (PEC1/2) link Ca 2+ and jasmonic acid signaling in plant cells.

Plants constantly encounter adverse environmental interactions. One organelle is particularly specialized in stress signaling and phytohormone synthesis: the plastid. Calcium (Ca 2+ ), a key second messenger, is known to intersect with cellular phytohormone signaling networks. While cytosolic Ca 2+ dynamics have been studied extensively, the physiological relevance of stromal Ca 2+ transients and the identity of channels mediating rapid Ca 2+ flux into plastids remain largely unexplored. In this

Structural insights into fosfomycin efflux by a streptococcal ABC transporter.

Gram-positive bacteria encode a broad array of ABC transporters that mediate substrate translocation across the cell membrane, with some contributing to their survival under environmental stresses such as antimicrobial exposure. While several of these transporters have been shown to exhibit multidrug efflux activity, the functional roles of many others remain unknown. Here, using an efflux pump screen in the opportunistic human pathogen Streptococcus pneumoniae , we identified a previously uncha

Detection of "hidden" mitotic crossovers by long-read DNA sequencing.

Mitotic crossovers in diploid organisms are usually detected by looking for loss of heterozygosity (LOH) for a marker. Assuming the crossover occurs between two duplicated chromatids, a single reciprocal crossover will result in two recombinant chromatids and two nonrecombinant chromatids. LOH will only be observed when a recombinant chromatid cosegregates with a nonrecombinant chromatid. Cells containing both recombinant chromosomes will not result in LOH. Below, we use long-range DNA sequencin

Amino acid homeostasis by CORVET/HOPS: A metabolic and stress resilience checkpoint for T cells.

Amino acid sufficiency is critical for T cell metabolic reprogramming, yet how T cells maintain amino acid homeostasis remains poorly defined. Here, we identify the CORVET and HOPS (CORVET/HOPS) tethering complexes as essential upstream regulators. In activated T cells, they sustain intracellular amino acid levels by promoting macropinocytosis to acquire extracellular nutrients. This function enables dual signaling outcomes: suppression of the integrated stress response (ISR) and activation of m

More in Health & Medicine →

Artificial Intelligence

Neural network-augmented Pfaffian wave-functions for scalable simulations of interacting fermions.

Developing accurate numerical methods for strongly interacting fermions is crucial for improving our understanding of various quantum many-body phenomena, especially unconventional superconductivity. Recently, neural quantum states have emerged as a promising approach for studying correlated fermions, highlighted by the hidden fermion and backflow methods, which use neural networks to model corrections to fermionic quasiparticle orbitals. In this work, we expand these ideas to the space of Pfaff

Why friends in common reveal network stars.

The Friendship Paradox states that, on average, your friends have more friends than you do. We extend this to common friends-those who appear in multiple people's friend lists. We show that the more people who share a common friend, the more connected that person tends to be, and we derive an expression quantifying this progression. In a regional Facebook network, a common friend to three randomly sampled individuals has on average more friends than 99.9% of the network. In a citation network, a

Sensory context improves language prediction in humans and LLMs.

Language is a fundamental human capacity. Large language models (LLMs) have presented the first viable model of language outside of humans, yet how these models learn and use language differs significantly from humans. Here, we compare LLMs and humans predicting language with varying levels of sensory information-from disembodied written text to audiovisual videos of speakers-to demonstrate that, in both humans and LLMs, sensory context is critical for optimal performance. We asked human partici

Treatment Decisions in Multiple Myeloma.

Revolutions in transplantation and targeted and immune therapies have transformed multiple myeloma from a disease with an associated survival of a few years into one for which functional cure is an emerging goal. This abundance of effective therapies has created clinical complexity. Here we provide a practical framework, anchored in trial evidence and informed by emerging biologic discoveries, for the navigation of treatment decisions across the disease spectrum. We outline how cytogenetic and g

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Physical/Tech

Multiband condensate of magnons in two dimensions.

Wavelike bosonic particles can accumulate in a single mode characterized by a particular wavelength, and such condensates are at the heart of phenomena such as superconductivity and superfluidity where usually a single complex number describes their state. If there are several flavors of excitations or particles, a vector containing several complex numbers can characterize multicomponent condensation, thus opening new possibilities for textures, dynamics, and devices. Thus far, multicomponent co

Indirect reciprocity with dual private assessment.

People often cooperate out of concern for their reputation. The corresponding theory of indirect reciprocity predicts that such cooperation can only evolve if people's opinions of each other are sufficiently correlated. This correlation, however, can be difficult to achieve when individuals form their opinions independently from one another, as in private assessment models. In that case, errors can generate disagreements that propagate throughout a population. Here, we identify a simple mechanis

A genetic program for rapid initiation of axillary meristems at the onset of flowering.

Shoot branching patterns and their diversity arise from variable activities of axillary meristems (AMs). A common feature of flowering plants is delayed AM initiation and growth during the vegetative phase, followed by a sudden and rapid acceleration of apical AM initiation during the reproductive phase. The mechanisms underlying this pronounced developmental shift are poorly understood. During tomato floral transition, the primary shoot meristem (PSM) terminates in a flower after producing two

David Botstein: A pioneering geneticist and educator 1942-2026.

David Botstein, who died on February 27, 2026, was a towering figure in the field of modern molecular genetics. His research career was largely focused on the development of methods to better understand biological systems, beginning with his early work on Salmonella phage P22 and yeast, where he exploited the use of conditional lethal mutations as suppressors to identify genes with common functions and to order them in a pathway. He is best remembered for developing restriction fragment length p

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Environment

Earthquake-triggered cascading hazards under Arctic amplification.

Arctic warming is reshaping permafrost and glacierized terrains, potentially changing their natural hazards in response to seismic shaking. On 10 March 2025, a Mw 6.5 oceanic transform fault earthquake near Jan Mayen Island in the Arctic Ocean triggered a large rock avalanche that buried part of the Kjerulf Glacier, generating infrasound signals and glacier calving. Using seismic, Global Navigation Satellite System data, infrasound records, satellite imagery, and long-term climatological records

At least a fivefold gap in effective global marine protection.

The Convention on Biological Diversity's ambitious target to "effectively conserve" 30% of the world's oceans in protected areas by 2030 risks being undermined by a primary focus on total area protected rather than realized conservation outcomes. Area-based assessments can overstate success because few marine protected areas (MPAs) possess strong restrictions and high compliance. Here, we estimate the extent that conservation outcomes are realized across the global MPA network for shallow reefs

Co-option of ancestral stem regulators drove recurrent evolution of underground storage organs.

Geophytes are plants that produce underground storage organs such as tubers, rhizomes, and bulbs, to facilitate asexual reproduction and withstand a myriad of environmental challenges. While the potato ( Solanum tuberosum L.) serves as the primary model for studying tuberization, the genetic mechanisms encoding this trait across diverse angiosperm lineages remains unclear. This study utilized a phylogenomic-transcriptomic approach to compare tuber development across nine tuberizing species with

The genomic origins and evolutionary path to a key innovation in the world's most venomous snakes.

Evolutionary innovation is a catalyst for the colonization of new environments and the adaptive radiations of major groups. Novel traits typically evolve through the modification of preexisting characters, but the genetic paths underlying their origin have been challenging to trace, and the general requirements for and relative order of different kinds of gene mutations have been difficult to assess. Here, we trace the genomic origins of four procoagulant venom toxins (factor X, factor V, group

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Society & Culture

Cerebellar microcircuits enable robust evidence-based decisions through cortico-cerebellar coupling.

The cerebellum is increasingly implicated in perceptual decision-making, yet it remains unclear how the cerebellar cortex can support sparse evidence accumulation over behavioral time scales without assuming cortical-style dense local excitatory recurrence. We present a biologically constrained modeling framework showing that cerebellar microcircuits can implement graded accumulation and competition in the absence of such recurrence. In our model, type-II Purkinje-neuron excitability generates f

Loss of neuronal population organization links pathology to behavior in a model of Alzheimer's disease.

Alzheimer's disease and related dementias are typically described at two levels: the accumulation of molecular pathology and the emergence of cognitive impairment. Understanding the relationship between pathology, often studied in animal models, and human cognition will require measurements spanning intermediate scales, including single neurons, neuronal populations, and distributed networks. Here we combine longitudinal measurements of behavior and neuronal population activity with fluid and hi

Deconstruction of lysergic acid diethylamide.

Of the classic psychedelics, lysergic acid diethylamide (LSD) is perhaps the best-known, but its complex chemical architecture has limited synthetic investigations aimed at generating analogues with improved safety and efficacy profiles. Here, we systematically deconstruct the tetracyclic ergoline core of LSD to create 9 simplified ergoline analogues (i.e., ergologs) and evaluate them in pharmacological assays relevant to 5-HT2A, 5-HT2B, and 5-HT2C receptor function. Our work revealed the key mo

A role for self-regulatory control in the absence of ingroup preference.

One of psychology's most ubiquitous findings is that of robust ingroup preference, an explicitly stated human preference for the groups to which we belong. The advent of implicit measures of social cognition introduced a paradoxical result: Compared to members of higher-status groups, members of lower-status groups often show no implicit ingroup preference, sometimes even showing outgroup preference, a result rarely observed on explicit measures. Prevailing theories have provided macro-level acc

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