Skip to main content
Health & Medicine

Climate change threatens malaria elimination in the Asia Pacific.

| Source: Nature medicine

Climate change threatens decades of progress toward malaria elimination across the Asia Pacific. In recent years, reported cases have increased sharply in several regions, including Pakistan following the 2022 floods. However, current research and adaptation strategies have largely focused on gradual warming and shifting transmission seasons and may not fully capture acute operational disruptions in endemic settings. Here we examine how climate change influences malaria through cascading disrupt

Climate change threatens decades of progress toward malaria elimination across the Asia Pacific. In recent years, reported cases have increased sharply in several regions, including Pakistan following the 2022 floods. However, current research and adaptation strategies have largely focused on gradual warming and shifting transmission seasons and may not fully capture acute operational disruptions in endemic settings. Here we examine how climate change influences malaria through cascading disruptions to health systems, population displacement and ecological change. As a multidisciplinary group of policymakers and researchers, we identify priority actions: integrating malaria control into disaster response, deploying adaptive vector control for displaced populations, strengthening cross-border data sharing, linking early warnings to anticipatory action, and incorporating land-use data into surveillance. Leveraging existing advances in climate policy, digital surveillance and community engagement will be critical. Sustaining elimination will require complementing long-term projections with preparedness for near-term system shocks.

Read the original source →

Related Stories

Health & Medicine

An innervated and vascularized HNSCC-on-a-chip model built on defined and tunable engineered extracellular matrices.

Understanding the tumor microenvironment requires experimental platforms that faithfully recapitulate its key components. Here, we present an innervated and vascularized head and neck squamous cell carcinoma (HNSCC)-on-a-chip platform built with fully defined and tunable engineered extracellular matrices (eECMs). In a stepwise increase of complexity, we first cocultured patient-derived HNSCC cells, cancer-associated fibroblasts, and endothelial cells within tailored eECMs, revealing extracellula

Continue reading
Health & Medicine

Septin binding restricts Shigella growth and triggers intracellular tolerance.

Pathogen survival relies on their ability to adapt to changing environments, yet how intracellular bacteria tolerate cell-autonomous immunity remains unclear. Septins assemble into cage-like structures around cytoplasmic Shigella targeted by autophagy, but their antibacterial activity was unknown. Using advanced microscopy and cell-free reconstitution, we show that septins polymerize into circumferentially oriented filaments that inhibit bacterial growth. RNA-sequencing reveals that septin bindi

Continue reading
Health & Medicine

DCAF6 reprograms TGF-β responses through TRIM33 destruction.

TGF-β signaling plays a pivotal role in regulating numerous cellular processes, primarily through the Smad-dependent pathway. Disruptions of the pathway are associated with developmental disorders and life-threatening diseases, such as cancer. It has been reported that TRIM33 inactivates Smad4 signaling and also drives its own signaling responses. However, the mechanism controlling TRIM33 activity has remained unclear. In this study, we identify DCAF6 as a previously unrecognized ubiquitin

Continue reading
Health & Medicine

Origami state machine with time-varying magnetic fields.

Achieving reliable, remote control over multiple stable states in modular systems remains a challenge due to the coupling between modules and history-dependent transitions. Here, we present magnetic origami state machines that enable deterministic navigation from any unknown initial state to any target state under magnetic actuation. By assuming mutually distinct energy barriers in modular Kresling origami assemblies, we realize fully accessible transition graphs with scalable state spaces. Guid

Continue reading
Health & Medicine

Deep mutational scanning of the GPCR rhodopsin reveals pleiotropic mutational effects and their roles in modulating receptor signaling.

Biophysical pleiotropy, the phenomenon in which a mutation affects multiple protein properties, underlies many genetic diseases and shapes protein evolution, yet remains poorly understood, limiting synthetic biology and therapeutic development. Although extensively studied in soluble proteins, little is known about how pleiotropic effects shaped the evolution of receptor protein functions. Here, we developed a cell-based assay designed to assess pleiotropic effects in G protein-coupled receptors

Continue reading