UTR-ly unexpected: RNA chaperones tame intrinsically disordered proteins.

July 23, 2026| Source: Cell

How do cells ensure that complex, multidomain proteins fold correctly? Luo et al. reveal a self-contained solution. The 3' UTR of an mRNA co-translationally chaperones the protein it encodes, preventing intrinsically disordered regions from making inappropriate contacts. This functionality, localized to mesh-like condensates, challenges Anfinsen's dogma and opens therapeutic possibilities.

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UTR-ly unexpected: RNA chaperones tame intrinsically disordered proteins.

Cryoelectron tomography reveals an age-related decline in mitoribosomes that contributes to T cell dysfunction in older individuals.

RelB NF-&#x3ba;B tunes Notch2 signaling to promote IL-23-secreting solitary isolated lymphoid tissue-resident DCs critical for gut immunity.

X-linked SYTL4 missense variant disrupts RAB27A-dependent vesicle trafficking and synaptic transmission in autism.

Folic acid prevention of neural tube defects requires retinoic acid produced by ALDH1L1.

Dynamic principles of concentration buffering through liquid-liquid phase separation.

RelB NF-κB tunes Notch2 signaling to promote IL-23-secreting solitary isolated lymphoid tissue-resident DCs critical for gut immunity.