Skip to main content
Health & Medicine

Physiotherapist-led care for musculoskeletal conditions in the emergency department (RESHAP-ED): a randomised controlled trial with economic evaluation.

| Source: Lancet (London, England)

Long stays in the emergency department compromise patient safety and health system performance. Physiotherapist-led models of care may improve care and emergency department performance, but their effects have not been rigorously evaluated in randomised trials. We compared the effectiveness, safety, and cost-effectiveness of physiotherapist-led care with usual care for patients presenting to the emergency department with musculoskeletal conditions. RESHAP-ED was an open-label, pragmatic, randomis

Long stays in the emergency department compromise patient safety and health system performance. Physiotherapist-led models of care may improve care and emergency department performance, but their effects have not been rigorously evaluated in randomised trials. We compared the effectiveness, safety, and cost-effectiveness of physiotherapist-led care with usual care for patients presenting to the emergency department with musculoskeletal conditions. RESHAP-ED was an open-label, pragmatic, randomised trial that recruited adults aged 18 years and older at five emergency departments in New South Wales, Australia, with uncomplicated musculoskeletal conditions (eg, soft tissue conditions, neck and back pain, and fractures or dislocations not requiring orthopaedic review or surgery). Participants were randomly assigned (1:1), using statistician-generated randomly permuted blocks, to either physiotherapist-led care (intervention) or usual physician-led or nurse practitioner-led care (control). The primary outcome was length of stay in the emergency department, calculated as time from arrival to discharge, analysed in the intention-to-treat population using a linear mixed-effects model. The trial was prospectively registered on the Australian New Zealand Clinical Trials Registry (ACTRN12623000782639) and is completed. Between Nov 22, 2023 and March 29, 2025, 4219 patients were screened, 2728 were deemed ineligible for inclusion, and 1491 participants were randomly assigned (746 assigned to the physiotherapy-led intervention group and 745 assigned to the physician-led or nurse-led practitioner control group). Following the exclusion of 16 participants after randomisation, 1475 were included in the analysis (737 in the intervention group and 738 in the control group). The mean age of participants was 40·1 years (SD 16·5). 719 (48·7%) participants were male, 755 (51·2%) were female, and one (0·1%) participant had unreported sex data. Follow-up for the primary outcome was 100% complete. The mean length of stay in the emergency department was 2·4 h in the intervention group and 3·4 h in the control group (-1·0 h [95% CI -1·2 to -0·8]). Adverse events were reported by 39 (6·6%) of 591 participants in the intervention group versus 33 (5·9%) of 555 in the control group (p=0·72). The intervention group had lower costs (-$35·1 [95% CI -69·0 to -1·7]) and a high probability (98·1%) of being cost-effective. A physiotherapist-led model of care in the emergency department reduced length of stay among patients presenting with uncomplicated musculoskeletal conditions, without compromising health outcomes or safety, and was cost-effective. Medical Research Future Fund.

Read the original source →

Related Stories

Health & Medicine

PLASTID ENVELOPE ION CHANNELS (PEC1/2) link Ca 2+ and jasmonic acid signaling in plant cells.

Plants constantly encounter adverse environmental interactions. One organelle is particularly specialized in stress signaling and phytohormone synthesis: the plastid. Calcium (Ca 2+ ), a key second messenger, is known to intersect with cellular phytohormone signaling networks. While cytosolic Ca 2+ dynamics have been studied extensively, the physiological relevance of stromal Ca 2+ transients and the identity of channels mediating rapid Ca 2+ flux into plastids remain largely unexplored. In this

Continue reading
Health & Medicine

Detection of "hidden" mitotic crossovers by long-read DNA sequencing.

Mitotic crossovers in diploid organisms are usually detected by looking for loss of heterozygosity (LOH) for a marker. Assuming the crossover occurs between two duplicated chromatids, a single reciprocal crossover will result in two recombinant chromatids and two nonrecombinant chromatids. LOH will only be observed when a recombinant chromatid cosegregates with a nonrecombinant chromatid. Cells containing both recombinant chromosomes will not result in LOH. Below, we use long-range DNA sequencin

Continue reading
Health & Medicine

Amino acid homeostasis by CORVET/HOPS: A metabolic and stress resilience checkpoint for T cells.

Amino acid sufficiency is critical for T cell metabolic reprogramming, yet how T cells maintain amino acid homeostasis remains poorly defined. Here, we identify the CORVET and HOPS (CORVET/HOPS) tethering complexes as essential upstream regulators. In activated T cells, they sustain intracellular amino acid levels by promoting macropinocytosis to acquire extracellular nutrients. This function enables dual signaling outcomes: suppression of the integrated stress response (ISR) and activation of m

Continue reading
Health & Medicine

Bright monomeric fluorescent protein elite-niRFP704 for two-channel near-infrared STED nanoscopy.

The near-infrared (NIR) spectral region is attractive for live-cell imaging, due to low autofluorescence and reduced phototoxicity. Some phytochrome-derived fluorescent proteins absorb and emit fluorescence in the NIR, but have short fluorescence lifetimes and relatively low quantum yields, requiring higher laser powers thus limiting their usefulness for live-cell superresolution microscopy. Using the bacterial phytochrome miRFP703 as a template, we screened for variants with longer fluorescence

Continue reading
Health & Medicine

Quantitative nanoscale imaging shows peptide-MHC I complexes are monomeric and spatially regulated in human dendritic cells.

Major histocompatibility complex class I (MHC I) molecules present antigenic peptides to cytotoxic T cells, a process central to immune surveillance. However, the nanoscale spatial organization of peptide-MHC I (pMHC I) on human dendritic cells (DCs), key initiators of cytotoxic T cell responses, remains largely unexplored. Here, we combine high-affinity soluble T cell receptors with DNA-based point accumulation for imaging in nanoscale topography (DNA-PAINT) to quantitatively map and count defi

Continue reading